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In this trial, canagliflozin reduced the risk for worsening kidney disease and death (a composite outcome of end-stage kidney disease, doubling of serum creatinine levels, or death from renal or cardiovascular causes), major adverse cardiovascular events, and hospitalizations for heart failure

Requires medical supervision dose escalation and side-effect monitoring are essential

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Systematic review and meta-analysis investigating moderators of long-term effects of exercise on cognition in healthy individuals